2016年4月7日

原著論文

2017

  1. Yamashita F, Fujita A, Sasa Y, Higuchi Y, Tsuda M, Hashida M. An evolutionary search algorithm for covariate models in population pharmacokinetic analysis. J Pharm Sci, in press
  2. Yanamoto S, Babazada H, Sakai S, Higuchi Y, Yamashita F, Hashida M. Anti-inflammatory effect of self-assembling glycol-split glycosaminoglycan-stearylamine conjugates in lipopolysaccharide-stimulated macrophages. Biol Pharm Bull, 40(4): 540-545 (2017)
  3. Baba H, Ueno Y, Hashida M, Yamashita F. Quantitative prediction of ionization effect on human skin permeability. Int J Pharm, 522(1-2): 222-233 (2017)
  4. Higashino T, Nakatsuji H, Fukuda R, Okamoto H, Imai H, Matsuda T, Tochio H, Shirakawa M, Tkachenko NV, Hashida M, Murakami T, Imahori H. Hexaphyrin as a potential theranostic dye for photothermal therapy and 19F magnetic resonance imaging. Chembiochem, in press
  5. Chantarasrivong C, Ueki A, Ohyama R, Unga J, Nakamura S, Nakanishi I, Higuchi Y, Kawakami S, Ando H, Imamura A, Ishida H, Yamashita F, Kiso M, Hashida M. Synthesis and functional characterization of novel sialyl LewisX mimic-decorated liposomes for E-selectin-mediated targeting to inflamed endothelial cells. Mol Pharm, 14(5): 1528-1537 (2017)
  6. Abdalkader R, Kawakami S, Unga J, Higuchi Y, Suzuki R, Maruyama K, Yamashita F, Hashida M. The development of mechanically formed stable nanobubbles intended for sonoporation-mediated gene transfection. Drug Deliv, 24(1): 320-327 (2017)
  7. Hatanaka W, Kawaguchi M, Sun X, Nagao Y, Ohshima H, Hashida M, Higuchi Y, Kishimura A, Katayama Y, Mori T. Use of membrane potential to achieve transmembrane modification with an artificial receptor. Bioconjug Chem, 28(2): 296-301 (2017)
  8. Ohta T, Hashida Y, Higuchi Y, Yamashita F, Hashida M. In vitro cellular gene delivery employing a novel composite material of single-walled carbon nanotubes associated with designed peptides with pegylation. J Pharm Sci, 106(3): 792-802 (2017)

2016

  1. Masuda M, Kawakami S, Wijagkanalan W, Suga T, Fuchigami Y, Yamashita F, Hashida M. Anti-MUC1 aptamer/negatively charged amino acid dendrimer conjugates for targeted delivery to human lung adenocarcinoma A549 cells. Biol Pharm Bull, 39(10): 1734-1738 (2016)
  2. Ohta T, Hashida Y, Yamashita F, Hashida M. Sustained release of mitomycin C from its conjugate with single-walled carbon nanotubes associated by pegylated peptide. Biol Pharm Bull, 39(10): 1687-1693 (2016)
  3. Morishita Y, Yoshioka Y, Takimura Y, Shimizu Y, Namba Y, Nojiri N, Ishizaka T, Takao K, Yamashita F, Takuma K, Ago Y, Nagano K, Mukai Y, Kamada H, Tsunoda S, Saito S, Matsuda T, Hashida M, Miyakawa T, Higashisaka K, Tsutsumi Y. Distribution of silver nanoparticles to breast milk and their biological effects on breast-fed offspring mice. ACS Nano, 10(9): 8180-8191 (2016)
  4. Katsumi H, Nishikawa M, Hirosaki R, Okuda T, Kawakami S, Yamashita F, Hashida M, Sakane T, Yamamoto A. Development of PEGylated cysteine-modified lysine dendrimers with multiple reduced thiols to prevent hepatic ischemia/reperfusion injury. Mol Pharm, 13(8): 2867-2873 (2016)
  5. Ose A, Toshimoto K, Ikeda K, Maeda K, Yoshida S, Yamashita F, Hashida M, Ishida T, Akiyama Y, Sugiyama Y. Development of a support vector machine-based system to predict whether a compound is a substrate of a given drug transporter using its chemical structure. J Pharm Sci, 105(7): 2222-2230 (2016)
  6. Ohta T, Hashida Y, Yamashita F, Hashida M. Development of novel drug and gene delivery carriers composed of single-walled carbon nanotubes and designed peptides with PEGylation. J Pharm Sci, 105(9): 2815-2824 (2016)
  7. Fumoto S, Taniguchi N, Ikai Y, Yoshikawa N, Miyamoto H, Sasaki H, Hashida M, Kawakami S, Nishida K. The insertion timing of PEGylated lipids to galactosylated lipoplexes is important for liver-selective transfection in mice. Gene Cell Ther, 1(1): 1-11 (2016)
  8. Suzuki R, Oda Y, Omata D, Nishiie N, Koshima R, Shiono Y, Sawaguchi Y, Unga J, Naoi T, Negishi Y, Kawakami S, Hashida M, Maruyama K. Tumor growth suppression by the combination of nanobubbles and ultrasound. Cancer Sci, 107(3): 217-223 (2016)
  9. Taniguchi Y, Kawakami S, Fuchigami Y, Oyama N, Yamashita F, Konishi S, Shimizu K, Hashida M. Optimization of renal transfection using a renal suction-mediated transfection method in mice. J Drug Target, 24(5): 450-456 (2016)

2015

  1. Baba H, Takahara J, Yamashita F, Hashida M. Modeling and prediction of solvent effect on human skin permeability using support vector regression and random forest. Pharm Res, 32(11): 3604-3617 (2015)
  2. Oda Y, Suzuki R, Mori T, Takahashi H, Natsugari H, Omata D, Unga J, Uruga H, Sugii M, Kawakami S, Higuchi Y, Yamashita F, Hashida M, Maruyama K. Development of fluorous lipid-based nanobubbles for efficiently containing perfluoropropane. Int J Pharm, 487(1-2): 64-71 (2015)
  3. Abdalkader R, Kawakami S, Unga J, Suzuki R, Maruyama K, Yamashita F, Hashida M. Evaluation of the potential of doxorubicin loaded microbubbles as a theranostic modality using a murine tumor model. Acta Biomater, 19: 112-118 (2015)
  4. Atobe T, Mori M, Yamashita F, Hashida M, Kouzuki H. Artificial neural network analysis for predicting human percutaneous absorption taking account of vehicle properties. J Toxicol Sci, 40(2): 277-294 (2015)
  5. Otani Y, Kawakami S, Mukai H, Fuchigami Y, Yamashita F, Hashida M. Long-term in vivo gene expression in mouse kidney using φC31 integrase and electroporation. J Drug Target, 23(5): 427-435 (2015)
  6. Shimizu K, Araki H, Sakata K, Tonomura W, Hashida M, Konishi S. Microfluidic devices for construction of contractile skeletal muscle microtissues. J Biosci Bioeng, 119(2): 212-216 (2015)
  7. Ueki A, Un K, Mino Y, Yoshida M, Kawakami S, Ando H, Ishida H, Yamashita F, Hashida M, Kiso M. Synthesis and evaluation of glyco-coated liposomes as drug carriers for active targeting in drug delivery systems. Carbohydr Res, 405: 78-86 (2015)

2014

  1. Babazada H, Yamashita F, Hashida M. Suppression of experimental arthritis with self-assembling glycol-split heparin nanoparticles via inhibition of TLR4-NF-κB signaling. J Control Release, 194: 295-300 (2014)
  2. Babazada H, Yamashita F, Yanamoto S, Hashida M. Self-assembling lipid modified glycol-split heparin nanoparticles suppress lipopolysaccharide-induced inflammation through TLR4-NF-κB signaling. J Control Release, 194: 332-340 (2014)
  3. Yoshida M, Kawakami S, Kono Y, Un K, Higuchi Y, Maruyama K, Yamashita F, Hashida M. Enhancement of the anti-tumor effect of DNA vaccination using an ultrasound-responsive mannose-modified gene carrier in combination with doxorubicin-encapsulated PEGylated liposomes. Int J Pharm, 475(1-2): 401-407 (2014)
  4. Nakanishi H, Higuchi Y, Yamashita F, Hashida M. Targeted gene integration using the combination of a sequence-specific DNA-binding protein and phiC31 integrase. J Biotechnol, 186: 139-147 (2014)
  5. Kurosaki T, Kawakami S, Higuchi Y, Suzuki R, Maruyama K, Sasaki H, Yamashita F, Hashida M. Kidney-selective gene transfection using anionic bubble lipopolyplexes with renal ultrasound irradiation in mice. Nanomedicine, 10(8): 1829-1838 (2014)
  6. Murakami T, Nakatsuji H, Morone N, Heuser JE, Ishidate F, Hashida M, Imahori H. Mesoscopic metal nanoparticles doubly functionalized with natural and engineered lipidic dispersants for therapeutics. ACS Nano, 8(7): 7370-7376 (2014)
  7. Zhou S, Hashida Y, Kawakami S, Mihara J, Umeyama T, Imahori H, Murakami T, Yamashita F, Hashida M. Preparation of immunostimulatory single-walled carbon nanotube/CpG DNA complexes and evaluation of their potential in cancer immunotherapy. Int J Pharm, 471(1-2): 214-223 (2014)
  8. Kono Y, Kawakami S, Higuchi Y, Maruyama K, Yamashita F, Hashida M. Antitumor effect of nuclear factor-κB decoy transfer by mannose-modified bubble lipoplex into macrophages in mouse malignant ascites. Cancer Sci, 105(8): 1049-1055 (2014)
  9. Yoshida M, Kawakami S, Un K, Kono Y, Higuchi Y, Yamashita F, Hashida M. Evaluation of inflammatory responses due to small interfering RNA transfer using unmodified- and mannose-modified bubble lipoplexes with ultrasound exposure in primary cultured macrophages. J Drug Target, 22(8): 732-738 (2014)
  10. Ukawa M, Akita H, Hayashi Y, Ishiba R, Tange K, Arai M, Kubo K, Higuchi Y, Shimizu K, Konishi S, Hashida M, Harashima H. Neutralized nanoparticle composed of SS-cleavable and pH-activated lipid-like material as a long-lasting and liver-specific gene delivery system. Adv Healthc Mater, 3(8): 1222-1229 (2014)
  11. Kono Y, Kawakami S, Higuchi Y, Maruyama K, Yamashita F, Hashida M. Tumour-associated macrophages targeted transfection with NF-κB decoy/mannose-modified bubble lipoplexes inhibits tumour growth in tumour-bearing mice. J Drug Target, 22(5): 439-449 (2014)
  12. Katsumi H, Nishikawa M, Nishiyama K, Hirosaki R, Nagamine N, Okamoto H, Mizuguchi H, Kusamori K, Yasui H, Yamashita F, Hashida M, Sakane T, Yamamoto A. Development of PEGylated serum albumin with multiple reduced thiols as a long-circulating scavenger of reactive oxygen species for the treatment of fulminant hepatic failure in mice. Free Radic Biol Med, 69: 318-323 (2014)
  13. Matsumura K, Sakai C, Kawakami S, Yamashita F, Hashida M. Inhibition of cancer cell growth by GRP78 siRNA lipoplex via activation of unfolded protein response. Biol Pharm Bull, 37(4): 648-653 (2014)
  14. Shimizu K, Zhang G, Kawakami S, Taniguchi Y, Hayashi K, Hashida M, Konish S. Liver suction-mediated transfection in mice using a pressure-controlled computer system. Biol Pharm Bull, 37(4): 569-575 (2014)
  15. Kurosaki T, Kawakami S, Higuchi Y, Suzuki R, Maruyama K, Sasaki H, Yamashita F, Hashida M. Development of anionic bubble lipopolyplexes for efficient and safe gene transfection with ultrasound exposure in mice. J Control Release, 176: 24-34 (2014)
  16. Hashida Y, Tanaka H, Zhou S, Kawakami S, Yamashita F, Murakami T, Umeyama T, Imahori H, Hashida M. Photothermal ablation of tumor cells using a single-walled carbon nanotube-peptide composite. J Control Release, 173: 59-66 (2014)
  17. Kono Y, Kawakami S, Higuchi Y, Yamashita F, Hashida M. In vitro evaluation of inhibitory effect of nuclear factor-kappaB activity by small interfering RNA on pro-tumor characteristics of M2-like macrophages. Biol Pharm Bull, 37(1): 137-144 (2014)

2013

  1. Takafuji Y, Higuchi Y, Muro A, Oshiro K, Kawakami S, Yamashita F, Hashida M. Factors influencing the surface modification of mesenchymal stem cells with fluorescein-pegylated lipids. Biol Pharm Bull, 36(11): 1731-1738 (2013)
  2. Mathew S, Murakami T, Nakatsuji H, Okamoto H, Morone N, Heuser JE, Hashida M, Imahori H. Exclusive photothermal heat generation by a gadolinium bis(naphthalocyanine) complex and inclusion into modified high-density lipoprotein nanocarriers for therapeutic applications. ACS Nano, 7(10): 8908-8916 (2013)
  3. Yamashita F, Sasa Y, Yoshida S, Hisaka A, Asai Y, Kitano H, Hashida M, Suzuki H. Modeling of rifampicin-induced CYP3A4 activation dynamics for the prediction of clinical drug-drug interactions from in vitro data. PLoS One, 8(9): e70330 (2013)
  4. Yoshida S, Yamashita F, Ose A, Maeda K, Sugiyama Y, Hashida M. Automated extraction of information on chemical-P-glycoprotein interactions from the literature. J Chem Inf Model, 53(10): 2506-2510 (2013)
  5. Ikemura M, Nishikawa M, Kusamori K, Fukuoka M, Yamashita F, Hashida M. Pivotal role of oxidative stress in tumor metastasis under diabetic conditions in mice. J Control Release, 170(2): 191-197 (2013)

2012

  1. Kurosaki T, Kawakami S, Suzuki R, Maruyama K, Sasaki H, Hashida M. Novel ultrasound-responsive gene carrier with ternary structure. Human Gene Ther, 23(10): A141-A142 (2012)
  2. Murakami T, Nakatsuji H, Inada M, Matoba Y, Umeyama T, Tsujimoto M, Isoda S, Hashida M, Imahori H. Photodynamic and photothermal effects of semiconducting and metallic-enriched single-walled carbon nanotubes. J Am Chem Soc, 134(43): 17862-17865 (2012)
  3. Saito K, Chang YF, Horikawa K, Hatsugai N, Higuchi Y, Hashida M, Yoshida Y, Matsuda T, Arai Y, Nagai T. Luminescent proteins for high-speed single-cell and whole-body imaging. Nat Commun, 3: 1262 (2012)
  4. Yoshida S, Yamashita F, Itoh T, Hashida M. Structure-activity relationship modeling for predicting interactions with pregnane X receptor by recursive partitioning. Drug Metab Pharmacokinet, 27(5): 506-512 (2012)
  5. Kasai H, Murakami T, Ikuta Y, Koseki Y, Baba K, Oikawa H, Nakanishi H, Okada M, Shoji M, Ueda M, Imahori H, Hashida M. Creation of pure nanodrugs and their anticancer properties. Angew Chem Int Ed Engl, 51(41): 10315-10318 (2012)
  6. Miyako E, Deguchi T, Nakajima Y, Yudasaka M, Hagihara Y, Horie M, Shichiri M, Higuchi Y, Yamashita F, Hashida M, Shigeri Y, Yoshida Y, Iijima S. Photothermic regulation of gene expression triggered by laser-induced carbon nanohorns. Proc Natl Acad Sci U S A, 109(19): 7523-7528 (2012)
  7. Hashida Y, Umeyama T, Mihara J, Imahori H, Tsujimoto M, Isoda S, Takano M, Hashida M. Development of a novel composite material with carbon nanotubes assisted by self-assembled peptides designed in conjunction with β-sheet formation. J Pharm Sci, 101(9): 3398-3412 (2012)
  8. Shimizu K, Kawakami S, Hayashi K, Kinoshita H, Kuwahara K, Nakao K, Hashida M, Konishi S. In vivo site-specific transfection of naked plasmid DNA and siRNAs in mice by using a tissue suction device. PLoS One, 7(7): e41319 (2012)
  9. Umemoto Y, Kawakami S, Otani Y, Higuchi Y, Yamashita F, Hashida M. Evaluation of long-term gene expression in mouse liver using PhiC31 integrase and hydrodynamic injection. Biol Pharm Bull, 35(7): 1182-1186 (2012)
  10. Tsukamoto M, Okuda T, Okamoto H, Higuchi Y, Kawakami S, Yamashita F, Hashida M. Bovine serum albumin as a lyoprotectant for preparations of DNA dry powder formulations using the spray-freeze drying method. Biol Pharm Bull, 35(7): 1178-1181 (2012)
  11. Un K, Kawakami S, Yoshida M, Higuchi Y, Suzuki R, Maruyama K, Yamashita F, Hashida M. Efficient suppression of murine intracellular adhesion molecule-1 using ultrasound-responsive and mannose-modified lipoplexes inhibits acute hepatic inflammation. Hepatology, 56(1): 259-269 (2012)
  12. Yamashita F, Fujita A, Zhang X, Sasa Y, Mihara K, Hashida M. Computer-based evolutionary search of nonlinear conversion function for establishing in vitro-in vivo correlation (IVIVC) of oral drug formulations. Drug Metab Pharmacokinet, 27(3): 280-285 (2012)
  13. Shimizu K, Kawakami S, Hayashi K, Mori Y, Hashida M, Konishi S. Implantable pneumatically actuated microsystem for renal pressure-mediated transfection in mice. J Control Release, 159(1): 85-91 (2012)
  14. Un K, Kono Y, Yoshida M, Yamashita F, Kawakami S, Hashida M. Enhancement of gene expression by transcriptional activation using doxorubicin-loaded liposome/pDNA complexes. Pharmazie, 67(5): 400-405 (2012)
  15. Zhou S, Kawakami S, Higuchi Y, Yamashita F, Hashida M. The involvement of NK cell activation following intranasal administration of CpG DNA lipoplex in the prevention of pulmonary metastasis and peritoneal dissemination in mice. Clin Exp Metastasis, 29(1): 63-70 (2012)
  16. Zheng Y, Nishikawa M, Ikemura M, Yamashita F, Hashida M. Development of bone-targeted catalase derivatives for inhibition of bone metastasis of tumor cells in mice. J Pharm Sci, 101(2): 552-557 (2012)
  17. Kurosaki T, Higuchi N, Kawakami S, Higuchi Y, Nakamura T, Kitahara T, Hashida M, Sasaki H. Self-assemble gene delivery system for molecular targeting using nucleic acid aptamer. Gene, 491(2): 205-209 (2012)

2011

  1. Chang KL, Higuchi Y, Kawakami S, Yamashita F, Hashida M. Development of lysine-histidine dendron modified chitosan for improving transfection efficiency in HEK293 cells. J Control Release, 156(2): 195-202 (2011)
  2. Shimizu K, Higuchi Y, Kozu Y, Hashida M, Konishi S. Development of a suction device for stabilizing in vivo real-time imaging of murine tissues. J Biosci Bioeng, 112(5): 508-510 (2011)
  3. Higuchi Y, Wu C, Chang K, Irie K, Kawakami S, Yamashita F, Hashida M. Polyamidoamine dendrimer-conjugated quantum dots for efficient labeling of primary cultured mesenchymal stem cells. Biomaterials, 32(28): 6676-6682 (2011)
  4. Un K, Kawakami S, Higuchi Y, Suzuki R, Maruyama K, Yamashita F, Hashida M. Involvement of activated transcriptional process in the efficient gene transfection using unmodified and mannose-modified bubble lipoplexes with ultrasound exposure. J Control Release, 156(3): 355-363 (2011)
  5. Nakanishi H, Higuchi Y, Kawakami S, Yamashita F, Hashida M. Comparison of piggyBac transposition efficiency between linear and circular donor vectors in mammalian cells. J Biotechnol, 154(4): 205-208 (2011)
  6. Un K, Kawakami S, Yoshida M, Higuchi Y, Suzuki R, Maruyama K, Yamashita F, Hashida M. The elucidation of gene transferring mechanism by ultrasound-responsive unmodified and mannose-modified lipoplexes. Biomaterials, 32(20): 4659-4669 (2011)
  7. Un K, Kawakami S, Suzuki R, Maruyama K, Yamashita F, Hashida M. Suppression of melanoma growth and metastasis by DNA vaccination using an ultrasound-responsive and mannose-modified gene carrier. Mol Pharm, 8(2): 553-554 (2011)
  8. Dinh TD, Higuchi Y, Kawakami S, Yamashita F, Hashida M. Evaluation of osteoclastogenesis via NFκB decoy/mannosylated cationic liposome-mediated inhibition of proinflammatory cytokine production from primary cultured macrophages. Pharm Res, 28(4): 742-751 (2011)
  9. Yamashita F, Feng C, Yoshida S, Itoh T, Hashida M. Automated information extraction and structure-activity relationship analysis of cytochrome P450 substrates. J Chem Inf Model, 51(2): 378-385 (2011)
  10. Wijagkanalan W, Kawakami S, Higuchi Y, Yamashita F, Hashida M. Intratracheally instilled mannosylated cationic liposome/NFκB decoy complexes for effective prevention of LPS-induced lung inflammation. J Control Release, 149(1): 42-50 (2011)

2010

  1. Ikemura M, Nishikawa M, Hyoudou K, Kobayashi Y, Yamashita F, Hashida M. Improvement of insulin resistance by removal of systemic hydrogen peroxide by PEGylated catalase in obese mice. Mol Pharm, 7(6): 2069-2076 (2010)
  2. Un K, Kawakami S, Suzuki R, Maruyama K, Yamashita F, Hashida M. Development of an ultrasound-responsive and mannose-modified gene carrier for DNA vaccine therapy. Biomaterials, 31(30): 7813-7826 (2010)
  3. Murakami T, Tsuchida K, Hashida M, Imahori H. Size control of lipid-based drug carrier by drug loading. Mol Biosyst, 6(5): 789-791 (2010)
  4. Mukai H, Kawakami S, Takahashi H, Satake K, Yamashita F, Hashida M. Key physiological phenomena governing transgene expression based on tissue pressure-mediated transfection in mice. Biol Pharm Bull, 33(9): 1627-1632 (2010)
  5. Miyano T, Wijagkanalan W, Kawakami S, Yamashita F, Hashida M. Anionic amino acid dendrimer-trastuzumab conjugates for specific internalization in HER2-positive cancer cells. Mol Pharm, 7(4): 1318-1327 (2010)
  6. Chang K, Higuchi Y, Kawakami S, Yamashita F, Hashida M. Efficient gene transfection by histidine-modified chitosan through enhancement of endosomal escape. Bioconjug Chem, 21(6): 1087-1095 (2010)
  7. Hirata K, Maruyama T, Watanabe H, Maeda H, Nakajou K, Iwao Y, Ishima Y, Katsumi H, Hashida M, Otagiri M. Genetically engineered mannosylated-human serum albumin as a versatile carrier for liver-selective therapeutics. J Control Release, 145(1): 9-16 (2010)
  8. Nakanishi H, Higuchi Y, Kawakami S, Yamashita F, Hashida M. PiggyBac transposon-mediated long-term gene expression in mice. Mol Ther, 18(4): 707-714 (2010)
  9. Pensri C, Kawakami S, Higuchi Y, Yamashita F, Hashida M. Enhanced growth inhibition of metastatic lung tumors by intravenous injection of ATRA-cationic liposome/IL-12 pDNA complexes in mice. Cancer Gene Ther, 17(7): 512-522 (2010)
  10. Murakami‌ T, Wijagkanalan‌ W, Hashida M, Tsuchida K. Intracellular drug delivery by genetically engineered high-density lipoprotein nanoparticles. Nanomedicine, 5(6): 867-879 (2010)
  11. Yamashita F, Itoh T, Yoshida S, Haidar MK, Hashida M. A novel multi-dimensional visualization technique for understanding the design parameters of drug formulations. Comput Chem Eng, 34: 1306-1311 (2010)
  12. Kurosaki T, Kitahara T, Kawakami S, Higuchi Y, Yamaguchi A, Nakagawa H, Kodama Y, Hamamoto T, Hashida M, Sasaki H. γ-Polyglutamic acid coated vectors for effective and safe gene therapy. J Control Release, 142(3): 404-410 (2010)
  13. Mizuno Y, Naoi T, Nishikawa M, Rattanakiat S, Hamaguchi N, Hashida M, Takakura Y. Simultaneous delivery of doxorubicin and immunostimulatory CpG motif to tumors using a plasmid DNA/doxorubicin complex in mice. J Control Release, 141(2): 252-259 (2010)
  14. Zhou S, Kawakami S, Yamashita F, Hashida M. Intranasal administration of CpG DNA lipoplex prevents pulmonary metastasis in mice. Cancer Lett, 287(1): 75-81 (2010)